According to Masanori Shino, JoJo’s Bizarre Adventure character designer, Anasui was planned to be introduced as a woman in JoJo’s Bizarre Adventure: Stone Ocean anime series. Shino revealed during an interview in the May 2022 issue of Ultra Jump that the manga creator, Hirohiko Araki, gave the anime series’ staff permission after the envisaged to feature Anasui as a woman in the anime series.
“I personally also like Anasui from their first appearance in the manga. It seems that Araki-sensei has said that the anime version of Anasui can be a woman, but if it had turned out that way…”
Anasui had a female appearance when first introduced in the manga, but later changed to a more masculine body.